Preferred Label : Allogeneic Anti-B7-H3 CAR Gamma Delta T-cells QH104;
NCIt synonyms : Allogeneic Anti-B7-H3 CAR-gamma-delta T Cells QH104; Allogeneic B7-H3 CAR-gdT-cells QH104; Allogeneic B7-H3 CAR-gamma Delta T Cells QH104;
NCIt definition : A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain
and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric
antigen receptor (CAR) targeting the immunoregulatory protein and tumor-associated
antigen (TAA) B7-homologue 3 (B7-H3, CD276), with potential immunomodulating and antineoplastic
activities. Upon administration, allogeneic anti-B7-H3 CAR gamma delta T-cells QH104
target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity
in B7-H3-expressing tumor cells. Gamma delta T-lymphocytes play a key role in the
activation of the immune system and do not require major histocompatibility complex
(MHC)-mediated antigen presentation to exert their cytotoxic effect. B7-H3, a type
I transmembrane protein and a member of the B7 co-stimulatory protein superfamily,
is overexpressed on certain tumor cell types and on various immune cells. It is a
negative regulator of the T-cell activation and its overexpression plays a key role
in tumor cell invasion and metastasis.;
Molecule name : QH-104; QH 104;
Origin ID : C201654;
concept_is_in_subset
- has_target
