Preferred Label : Anti-PD-1 siRNA PH-762;
NCIt synonyms : RNAi Therapeutic PH-762; RNA interference Therapeutic PH-762; Anti-PD-1 RNAi PH-762;
NCIt definition : A self-delivering small-interfering RNA (siRNA) targeting the negative immunoregulatory
human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon intratumoral administration,
anti-PD-1 siRNA PH-762 binds to and destroys mRNA PD-1, thereby preventing the expression
of PD-1. As PD1-mediates the downregulation of T-cell activation and proliferation,
PH-762 is able to restore immune function and activates a cytotoxic T-lymphocyte (CTL)-mediated
immune response against tumor cells. This may lead to an inhibition of tumor cell
proliferation. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF)
expressed on T-cells, functions as an immune checkpoint that negatively regulates
T-cell activation and effector function when activated by its ligands PD-L1 (cluster
of differentiation 274; CD274) or 2 (PD-L2; CD273); it plays an important role in
tumor evasion from host immunity.;
Molecule name : PH-762; PH 762;
NCI Metathesaurus CUI : CL1920840;
Origin ID : C201650;
UMLS CUI : C5907915;
Semantic type(s)
- concept_is_in_subset
