Preferred Label : ATM Inhibitor SYH2051;
NCIt synonyms : ATM KInase Inhibitor SYH2051;
NCIt definition : An orally bioavailable inhibitor of ataxia telangiectasia mutated (ATM) kinase, with
potential chemo-and radio-sensitizing and antineoplastic activities. Upon oral administration,
ATM inhibitor SYH2051 selectively targets and binds to ATM, thereby inhibiting the
kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint
activation, disrupts DNA damage repair, induces apoptosis in damaged tumor cells,
and leads to cell death in ATM-overexpressing tumor cells. SYH2051 hypersensitizes
tumors to chemo/radiotherapy. ATM, a serine/threonine protein kinase belonging to
the phosphatidylinositol 3-kinase-related kinase (PIKK) family of protein kinases,
is upregulated in a variety of cancer cell types. It is activated in response to DNA
double-strand breaks (DSB) and plays a key role in DNA repair.;
Molecule name : SYH-2051; SYH 2051;
Origin ID : C201647;
concept_is_in_subset
