GTP Cyclohydrolase 1

Preferred Label : GTP Cyclohydrolase 1;

NCIt synonyms : GTP Cyclohydrolase I; EC 3.5.4.16; Guanosine 5'-Triphosphate Cyclohydrolase I; GCH1; GTP-CH-I;

NCIt definition : GTP cyclohydrolase 1 (250 aa, 28 kDa) is encoded by the human GCH1 gene. This protein is involved in the conversion of GTP to D-erythro-7,8-dihydroneopterin triphosphate, which is the first step in tetrahydrobiopterin (BH4) synthesis.;

Details

Origin ID

C201642;

OMIM relation
- Gtp cyclohydrolase I [OMIM gene]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GCH1 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Epidermis [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- GTPase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Folate Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Biosynthetic Process [NCIt concept]
- Cellular Stress Response [NCIt concept]
- Folic Acid Metabolic Process [NCIt concept]
- Hydrolysis [NCIt concept]

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