SMARCB1-Deficient Sinonasal Adenocarcinoma

Preferred Label : SMARCB1-Deficient Sinonasal Adenocarcinoma;

NCIt synonyms : Sinonasal SMARCB1-Deficient Adenocarcinoma;

NCIt definition : An SWI/SNF-deficient sinonasal carcinoma characterized by inactivating mutation of SMARCB1 gene. It usually affects the nasal sinuses. It is composed of malignant epithelial cells with a predominantly oncocytoid/plasmacytoid morphology and prominent glandular formations.;

Neoplastic status : Malignant;

Details

Origin ID

C201636;

Disease excludes abnormal cell
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Has associated anatomic sites
- Head and Neck [NCIt concept]
- Sinonasal Tract [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_finding
- Aggressive Clinical Course [NCIt concept]
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- SWI/SNF Complex Deficiency [NCIt concept]
disease_has_molecular_abnormality
- SMARCB1 Gene Inactivation [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Sinonasal Tract [NCIt concept]
disease_mapped_to_gene
- SMARCB1 Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- SMARCB1 Gene [NCIt concept]
- SMARCB1 wt Allele [NCIt concept]

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