STING Agonist CRD3874

Preferred Label : STING Agonist CRD3874;

NCIt definition : An allosteric agonist of all isoforms of stimulator of interferon genes protein (STING; transmembrane protein 173; TMEM173), with potential immunoactivating and antineoplastic activities. Upon administration, STING agonist CRD3874 targets and allosterically binds to STING, thereby activating the STING pathway in immune cells in the tumor microenvironment (TME). This leads to the production of pro-inflammatory cytokines, including interferons (IFNs), enhances the cross-presentation of tumor-associated antigens (TAAs) by antigen-presenting cells (APCs), including dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. STING, a transmembrane protein that activates immune cells in the TME, plays a key role in the activation of the innate immune system.;

Molecule name : CRD 3874; CRD-3874; CRD3874-SI;

NCI Metathesaurus CUI : CL1920444;

Details

Origin ID

C201525;

UMLS CUI

C5854656;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Stimulator of Interferon Genes Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

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