Preferred Label : STING Agonist CRD3874;
NCIt definition : An allosteric agonist of all isoforms of stimulator of interferon genes protein (STING;
transmembrane protein 173; TMEM173), with potential immunoactivating and antineoplastic
activities. Upon administration, STING agonist CRD3874 targets and allosterically
binds to STING, thereby activating the STING pathway in immune cells in the tumor
microenvironment (TME). This leads to the production of pro-inflammatory cytokines,
including interferons (IFNs), enhances the cross-presentation of tumor-associated
antigens (TAAs) by antigen-presenting cells (APCs), including dendritic cells (DCs),
and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer
cells. STING, a transmembrane protein that activates immune cells in the TME, plays
a key role in the activation of the innate immune system.;
Molecule name : CRD 3874; CRD-3874; CRD3874-SI;
Origin ID : C201525;
concept_is_in_subset
- has_target
