Preferred Label : EGFR-targeted IL-2/IL-10 Dual Cytokine Fusion Protein DK210 (EGFR);
NCIt synonyms : Diakine DK210 (EGFR); EGFR-targeted IL-10/IL-2 Fusion Protein DK210 (EGFR);
NCIt definition : A dual cytokine fusion protein comprised of high-affinity interleukin-10 (IL-10),
fused to a single chain variable fragment (scFv) scaffolding system that is linked
to wild-type interleukin-2 (IL-2) in the hinge region of the scFv, in which six complementarity
determining regions (CDRs) of the scFv are replaced by CDRs from an anti-epidermal
growth factor receptor (EGFR) monoclonal antibody, with potential immunomodulating
and antineoplastic activities. Upon subcutaneous administration, EGFR-targeted IL-2/IL-10
dual cytokine fusion protein DK210 (EGFR) targets and binds to EGFR expressed on tumor
cells. This allows the IL-2 moiety to specifically bind to IL-2 receptor (IL-2R) and
activate IL-2R-mediated signaling in CD8 T-cells in the tumor microenvironment (TME).
This enhances cytotoxic T-lymphocyte (CTL)-mediated cytotoxic immune responses against
tumor cells. IL-10 stimulates the differentiation and expansion of tumor specific
cytotoxic CD8 T-cells, thereby further enhancing the CTL-mediated cytotoxic immune
responses against tumor cells. IL-10 may also reduce the toxicities of IL-2 by suppressing
the secretion of pro-inflammatory cytokines associated with IL-2 toxicities. EGFR,
overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation,
tumor angiogenesis and radio- and chemoresistance.;
Molecule name : DK210 (EGFR); DK2 10 (EGFR);
Origin ID : C201499;
concept_is_in_subset
- has_target
