Preferred Label : RNA-lipoplex Cancer Vaccine BNT116;
NCIt synonyms : FixVac Lung BNT116; Cancer Vaccine BNT116; mRNA-derived NSCLC Vaccine BNT116;
NCIt definition : A RNA-lipoplex (RNA-LIP)-based cancer vaccine containing six messenger ribonucleic
acids (mRNA) each encoding for a different tumor-associated antigen (TAA) expressed
in non-small cell lung cancer (NSCLC), encapsulated in liposomes, with potential antineoplastic
activity. Upon intravenous administration of the RNA-lipoplex cancer vaccine BNT116,
the liposomes protect the RNA from degradation in the bloodstream, travel to the spleen
and are taken up by antigen-presenting cells (APCs). The RNA is translocated to the
cytoplasm and translated into the six tumor-associated proteins. The expressed proteins
are processed and the human leukocyte antigen (HLA)-peptide complexes are presented
to the immune system. This results in the production of various pro-inflammatory cytokines
and induces antigen-specific CD8 and CD4 T-cell responses against the six selected
TAAs.;
Molecule name : BNT 116; BNT-116;
NCI Metathesaurus CUI : CL1920408;
Origin ID : C201496;
UMLS CUI : C5854652;
Semantic type(s)
- concept_is_in_subset
