Preferred Label : Liposomal iNKT Agonist PORT-2;
NCIt synonyms : IMM60 Liposome Formulation PORT-2; Liposomal Invariant Natural Killer T-cell Agonist PORT-2;
NCIt definition : A liposomal formulation of IMM60, a synthetically derived small molecule agonist of
natural killer T-cells (NKTs) expressing an invariant (alpha, beta) T-cell receptor
(iNKTs), with potential immunomodulating and antineoplastic activities. Upon intravenous
administration of liposomal iNKT agonist PORT-2, IMM60 targets and binds to the T-cell
receptor on iNKTs, thereby activating iNKTs. In turn, iNKTs recognize CD1d-restricted
lipid ligands, which are expressed on certain tumor cells, and secrete large amounts
of various pro-inflammatory cytokines, including interferon-gamma (IFNg). This may
activate the immune system against tumor cells. Additionally, iNKTs directly target
and lyse CD1d-expressing tumor cells.;
Molecule name : PORT 2; PORT-2;
NCI Metathesaurus CUI : CL1920417;
Origin ID : C201490;
UMLS CUI : C5854651;
Semantic type(s)
- concept_is_in_subset
- has_target
