Preferred Label : Anti-CD38 scFv/Anti-DOTA scFv Fusion Protein CD38-SADA;
NCIt synonyms : Anti-CD38 scFv/Anti-DOTA scFv/SADA Domain Fusion Protein CD38-SADA; CD38-SADA;
NCIt definition : A fusion protein composed of a single chain variable fragment (scFv) targeting the
human cell surface glycoprotein and tumor-associated antigen (TAA) CD38, an scFv targeting
the chelating agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)
and a self-assembling and disassembling (SADA) domain that can self-assemble from
a monomeric polypeptide into tetrameric protein, that may be used as a pre-targeted
radioimmunotherapeutic agent. Upon administration, anti-CD38 scFv/anti-DOTA scFv fusion
protein CD38-SADA assembles in tetramers and the anti-CD38 scFv binds to CD38-expressing
tumor cells. The unbound CD38-SADA is excreted. Upon administration of a DOTA-based
radioactive payload, the anti-DOTA scFv binds to the DOTA moiety of the radioactive
payload, and radiation is selectively delivered to tumor cells expressing CD38. CD38,
a type II transmembrane glycoprotein, is present on various immune cells and hematologic
malignancies; its expression has been correlated with poor prognosis.;
Origin ID : C201289;
concept_is_in_subset
- has_target
