Preferred Label : Allogeneic Anti-CD6 CAR T-regulatory Cells;
NCIt synonyms : CD6-CAR Tregs; Allogeneic Anti-CD6 CAR Tregs; Allogeneic Anti-CD6 CAR-expressing T Regulatory Cells;
NCIt definition : A preparation of allogeneic T-regulatory cells (Tregs) that have been genetically
modified to express a chimeric antigen receptor (CAR) targeting the T-cell differentiation
antigen CD6, with potential immunmodulating activity. Upon administration, the allogeneic
anti-CD6 CAR Tregs may promote immunologic homeostasis and prevent autoimmunity. This
may induce tolerance to allogeneic hematopoietic stem cell transplants, prevent graft-versus-host
disease (GvHD), and suppress autoimmune pathology. The allogeneic anti-CD6 CAR Tregs
also targets and binds to CD6, which may prevent CD6-mediated activation pathways,
downregulate the activation and differentiation of T-cells, and reduce the synthesis
of pro-inflammatory cytokines. CD6, a co-stimulatory molecule predominantly expressed
on lymphocytes, is involved in the adhesion and maturation of T-cells.;
Origin ID : C201288;
concept_is_in_subset
- has_target
