Preferred Label : Lutetium Lu 177-PNT6555;
NCIt synonyms : [Lu-177]-PNT6555; 177Lu-PNT6555;
NCIt definition : A radioconjugate composed of PNT6555, a fibroblast activation protein (FAP)-targeting
moiety linked to the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic
acid (DOTA), radiolabeled with the beta-emitting radioisotope lutetium Lu 177 (177Lu),
with potential antineoplastic activity. Upon administration of lutetium Lu 177-PNT6555,
the FAP-targeting moiety targets and binds to FAP-expressing cancer-associated fibroblasts
(CAFs) and FAP-expressing tumor cells. Upon binding, FAP-expressing CAFs and tumor
cells are destroyed by 177Lu through the specific delivery of beta particle radiation.
FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment
(TME) and certain tumor cells.;
Origin ID : C201281;
concept_is_in_subset
- has_target
