NCIt synonyms : Immunoglobulin G Subclass 1; Immunoglobulin G1;
NCIt definition : The most abundant immunoglobulin G (IgG) subclass in the circulation of healthy individuals.
The IgG1 core hinge sequence contains 15 amino acids and two interchain disulfide
bonds. This subtype has high affinity for binding both Fc receptors and complement
component C1q. IgG1 is the predominant antibody subclass that responds to antigens
derived from both soluble and membrane proteins. Reduced levels of circulating IgG1
can indicate the presence of a variety of primary and secondary antibody deficiencies,
which can result in hypogammaglobulinemia.;