IgG1 - CISMeF

Preferred Label : IgG1;

NCIt synonyms : Immunoglobulin G Subclass 1; Immunoglobulin G1;

NCIt definition : The most abundant immunoglobulin G (IgG) subclass in the circulation of healthy individuals. The IgG1 core hinge sequence contains 15 amino acids and two interchain disulfide bonds. This subtype has high affinity for binding both Fc receptors and complement component C1q. IgG1 is the predominant antibody subclass that responds to antigens derived from both soluble and membrane proteins. Reduced levels of circulating IgG1 can indicate the presence of a variety of primary and secondary antibody deficiencies, which can result in hypogammaglobulinemia.;

NCI Metathesaurus CUI : CL1920624;

PubMed : 25368619;

Details

Origin ID

C201279;

UMLS CUI

C0020855;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- IgG subclass 1 [LOINC component]
- IgG1 [MeSH concept]
- IgG1 [LOINC part]
- Immunoglobulin IgG1 (substance) [SNOMED CT concept]
- immunoglobulin igg1 [SNOMED Notion]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
gene_product_has_biochemical_function
- Antibody [NCIt concept]
gene_product_has_chemical_classification
- Protein or Riboprotein Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Binding [NCIt concept]
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]
has_gene_product_element
- Immunoglobulin Heavy Constant Gamma 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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