IgG2 - CISMeF

Preferred Label : IgG2;

NCIt synonyms : Immunoglobulin G Subclass 2; Immunoglobulin G2;

NCIt definition : The second most abundant immunoglobulin G (IgG) subclass in the circulation of healthy individuals. The IgG2 core hinge sequence contains 12 amino acids and up to four interchain disulfide bonds. This subtype has low affinity for binding both Fc receptors and complement component C1q. The production of this IgG2 is stimulated by exposure to bacterial capsular polysaccharides and other antigenic glycans.;

NCI Metathesaurus CUI : CL1920623;

PubMed : 25368619;

Details

Origin ID

C201278;

UMLS CUI

C0020856;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- IgG subclass 2 [LOINC component]
- IgG2 [MeSH concept]
- IgG2 [LOINC part]
- Immunoglobulin IgG2 (substance) [SNOMED CT concept]
- immunoglobulin igg2 [SNOMED Notion]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
gene_product_has_biochemical_function
- Antibody [NCIt concept]
gene_product_has_chemical_classification
- Protein or Riboprotein Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Binding [NCIt concept]
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]
has_gene_product_element
- Immunoglobulin Heavy Constant Gamma 2 [NCIt concept]

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