Preferred Label : CD3 /CD19 Cell-depleted Autologous Hematopoietic Stem Cells;
NCIt synonyms : Autologous CD3 /CD19 Cell-depleted HSCs; CD3 /CD19 Cell-depleted Autologous HSCs;
NCIt definition : A preparation of autologous hematopoietic stem cells (HSCs) that have been selectively
depleted of CD3-positive (CD3 ) T-cells and CD19-positive (CD19 ) B-cells, with potential
immune reconstituting activity. Upon administration, the CD3 /CD19 cell-depleted
autologous HSCs are used for autologous stem cell transplant (ASCT) and may allow
for rapid and sustained engraftment and immune reconstitution without the autoreactive
CD3 T-cells and CD19 B-cells. This may alleviate manifestations of autoimmune diseases
such as systemic lupus erythematosus (SLE) and systemic sclerosis.;
NCI Metathesaurus CUI : CL1920531;
Origin ID : C201219;
UMLS CUI : C5856664;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
