Preferred Label : STING Agonist BI 1387446;
NCIt definition : An agonist of stimulator of interferon genes protein (STING; transmembrane protein
173; TMEM173), with potential immunoactivating and antineoplastic activities. Upon
intratumoral administration, STING agonist BI 1387446 targets and binds to STING and
activates the STING pathway in immune cells in the tumor microenvironment (TME). This
leads to the production of pro-inflammatory cytokines, including interferons (IFNs),
enhances the cross-presentation of tumor-associated antigens (TAAs) by antigen-presenting
cells (ADCs), including dendritic cells (DCs), and induces a cytotoxic T-lymphocyte
(CTL)-mediated immune response against cancer cells. STING, a transmembrane protein
that activates immune cells in the TME, plays a key role in the activation of the
innate immune system.;
Molecule name : BI-1387446; BI 1387446;
Origin ID : C201207;
concept_is_in_subset
- has_target
