Matuzumab - CISMeF

Preferred Label : Matuzumab;

NCIt related terms : EMD 72000;

NCIt definition : A humanized monoclonal antibody with antineoplastic activity. Matuzumab binds the epidermal growth factor receptor (EGFR) with high affinity, competitively blocking natural ligand binding and inhibiting receptor-mediated downstream signalling, resulting in impaired tumor cell proliferation.;

Alternative definition : NCI-GLOSS: A monoclonal antibody that is being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. EMD 72000 binds to the epithelial growth factor receptor (EGFR) on tumor cells and blocks growth signals.;

UNII : MG4M3QB242;

CAS number : 339186-68-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 339186-68-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : EMD 72000;

Codes from synonyms : CDR0000434600; CDR0000430873;

Details

Origin ID

C2012;

UMLS CUI

C1328134;

Automatic exact mappings (from CISMeF team)
- EMD 72000 [MeSH concept]
Currated CISMeF NLP mapping
- matuzumab [MeSH concept]
- matuzumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- matuzumab [MeSH Supplementary Concept]
- matuzumab [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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