NCIt definition : A humanized monoclonal antibody with antineoplastic activity. Matuzumab binds the
epidermal growth factor receptor (EGFR) with high affinity, competitively blocking
natural ligand binding and inhibiting receptor-mediated downstream signalling, resulting
in impaired tumor cell proliferation.;
Alternative definition : NCI-GLOSS: A monoclonal antibody that is being studied in the treatment of some types
of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind
to cancer cells. EMD 72000 binds to the epithelial growth factor receptor (EGFR) on
tumor cells and blocks growth signals.;
UNII : MG4M3QB242;
CAS number : 339186-68-4;
Molecule name : EMD 72000;
Codes from synonyms : CDR0000434600; CDR0000430873;