Preferred Label : Anti-CA19-9 Antibody hu5B1/TCO Immunoconjugate;
NCIt synonyms : Trans-cyclooctene-hu5B1 Immunoconjugate; hu5B1-TCO;
NCIt definition : An immunoconjugate composed of the recombinant human monoclonal antibody hu5B1, which
targets the carbohydrate antigen sialyl Lewis A (carbohydrate antigen 19-9; CA19-9),
that is conjugated to trans-cyclooctene (TCO), with potential use in pretargeted radioimmunotherapy
(PRIT). Upon intravenous administration of anti-CA19-9 antibody hu5B1/TCO immunoconjugate
(hu5B1-TCO), the anti-CA19-9 antibody moiety targets and binds to CA19-9-expressing
tumor cells and unbound hu5B1-TCO is readily cleared from the body. Imaging of CA19-9-expressing
cells using positron emission tomography (PET) can occur upon administration of copper
Cu 64-Tz-SarAr, a tetrazine-based radioligand that binds to the TCO moiety of bound
hu5B1-TCO. CA19-9, overexpressed on a number of different tumor cell types, plays
a key role in tumor cell survival and metastasis.;
NCI Metathesaurus CUI : CL1920507;
Origin ID : C201189;
UMLS CUI : C5856653;
Semantic type(s)
- concept_is_in_subset
- has_target
