Preferred Label : IL-12-Fc Fusion Protein XmAb662;
NCIt synonyms : XmAb-662;
NCIt definition : An engineered potency-reduced fusion protein composed of the human pro-inflammatory
cytokine interleukin-12 (IL-12) fused to a Fc domain, with potential immunomodulatory
and antineoplastic activities. Upon administration of IL-12-Fc fusion protein XmAb662,
IL-12 activates the immune system by promoting the secretion of interferon-gamma (IFN-g)
and activating CD8 T-cells, CD4 T-cells and natural killer cells (NKs). The activation
and expansion of these immune cells mediate cytolytic immune responses against tumor
cells, thereby killing tumor cells and inhibiting tumor cell proliferation. The Fc
domain prolongs the half-life and exposure in the tumor.;
Molecule name : XmAb662; XmAb 662;
Origin ID : C201152;
chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
