NCIt definition : A monoclonal antibody directed against human killer cell immunoglobulin-like receptor
3DL3 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic
tail 3; KIR3DL3), an inhibitory receptor for human endogenous retrovirus-H long terminal
repeat-associating protein 2 (HHLA2; B7 homolog 7; B7-H7), with potential immune checkpoint
inhibitory and antineoplastic activities. Upon administration, anti-KIR3DL3 monoclonal
antibody NPX267 binds to KIR3DL3 expressed on T- and natural killer (NK) cells and
prevents the binding of KIR3DL3 to HHLA2 expressed on tumor cells. This abrogates
the KIR3DL3/HHLA2-mediated inhibition of T-cell and NK cell activation in the tumor
microenvironment (TME), which may lead to enhanced cytotoxic T-lymphocyte (CTL)-mediated
immune response and NK cell cytotoxicity against cancer cells. HHLA2, a member of
the B7 family of immune modulators, is upregulated in a variety of tumor cell types.
The KIR3DL3-HHLA2 pathway is an immunosuppressive pathway and a negative regulator
of T-cell and NK cell activation.;
Semantic type(s)