Preferred Label : DNA Plasmid Vaccine ITI-1001;
NCIt synonyms : pDNA Vaccine ITI-1001; IE-1/pp65/gB-encoding pDNA Vaccine ITI-1001; CMV Antigens Vaccine ITI-1001; DNA Vaccine ITI-1001;
NCIt definition : An off-the-shelf (OTS) plasmid DNA cancer vaccine containing two DNA plasmids, one
encoding for the two human cytomegalovirus (CMV) antigens immediate-early 1 (IE-1)
and the matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) fused to the
lysosome-associated membrane protein 1 (LAMP-1), and one plasmid encoding for the
CMV glycoprotein B (gB) antigen which is also fused to LAMP-1, with potential immunomodulating
and antineoplastic activities, Upon intramuscular (IM) administration and following
electroporation, the DNA plasmid vaccine ITI-1001 is taken up by antigen presenting
cells (APCs) and transported via LAMP-1 and the lysosome-mediated pathway. This results
in enhanced major histocompatibility (MHC) class II antigen presentation of the three
antigens to the immune system, thereby promoting CD4-positive T-cell responses as
well as CD8-positive T-cell responses against tumor cells expressing the three viral
antigens. IE1, pp65 and gB are expressed in certain tumor types. The incorporation
of LAMP-1 routes the CMV antigens into the lysosomal compartment.;
Molecule name : ITI 1001; ITI-1001;
NCI Metathesaurus CUI : CL1920481;
Origin ID : C201131;
UMLS CUI : C5854631;
Semantic type(s)
- concept_is_in_subset
- has_target
