Preferred Label : BCMA-TGF-beta Insensitive Armored CAR T Cells;
NCIt synonyms : BCMA TGFb-resistant CAR-T cells; Anti-BCMA TGF-beta-insensitive CAR-T Cells; Anti-BCMA-CAR-expressing TGF-beta Insensitive T-cells;
NCIt definition : A preparation of human T-lymphocytes genetically engineered to express a chimeric
antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell maturation
antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and
armored to be insensitive to the immunosuppressive cytokine transforming growth factor-beta
(TGF-beta), with potential immunostimulating and antineoplastic activities. Upon administration,
BCMA-TGF-beta insensitive armored CAR T cells specifically recognize and induce selective
toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing
ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis
factor receptor superfamily (TNFRSF). BCMA, found on the surfaces of plasma cells
and overexpressed on malignant plasma cells, plays a key role in plasma cell proliferation
and survival. Though the nature of the TGF-beta armor has yet to be fully elucidated,
it prevents the binding of TGF-beta to the CAR T-cells. TGF-beta negatively regulates
T-cell proliferation and activation, contributes to the immunosuppressive nature of
the tumor microenvironment (TME), and plays a key role in promoting tumor initiation,
metastasis, and suppressing anti-tumor immunity.;
NCI Metathesaurus CUI : CL1915452;
Origin ID : C201071;
UMLS CUI : C5856617;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
