Preferred Label : Oncolytic VSV-GP BI 1821736;
NCIt synonyms : Oncolytic VSV-GP-huCD80Fc BI 1821736; VSV-GP BI 1821736;
NCIt definition : An oncolytic virus derived from the vesicular stomatitis virus (VSV), a single-stranded
RNA virus, and containing a genetically modified glycoprotein (GP) and a human CD80
(B7.1) Fc fragment, with potential immunomodulating and antineoplastic activities.
Upon administration, oncolytic VSV-GP BI 1821736 preferentially replicates in tumor
cells, and induces VSV-mediated cytolytic activity towards the tumor cells. Viral
infection also stimulates the immune system to recognize these same tumor cells, leading
to immune-mediated killing of both infected and non-infected tumor cells, thereby
further killing tumor cells. In addition, BI 1821736 secretes CD80, which targets
and binds to CD28, and in the presence of antigenic T-cell receptor (TCR) signaling
leads to the co-stimulation of T-cell responses including the activation of naive
and memory T-cells. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response
against cancer cells, thereby killing cancer cells.;
Molecule name : BI 1821736; BI-1821736;
Origin ID : C200910;
concept_is_in_subset
