Preferred Label : Modified Influenza Virus Expressing HPV16 E6/E7 FluBHPVE6E7;
NCIt synonyms : delNS Influenza Virus Expressing HPV16 E6/E7 FluBHPVE6E7; FluBHPVE6E7;
NCIt definition : A cancer vaccine comprised of a modified influenza viral vector that lacks the C-terminal
part of the non-structural gene NS1 (delNS) encoding the tumor-associated antigens
(TAAs) human papillomavirus type 16 (HPV16) E6 and E7, with potential immunostimulating
and antineoplastic activities. Upon administration, modified influenza virus expressing
HPV16 E6/E7 FluBHPVE6E7 stimulates the host immune system to mount a cytotoxic T-lymphocyte
(CTL) response against tumor cells expressing HPV16 E6 and E7, resulting in tumor
cell lysis. HPV16 E6 and E7 are oncoproteins that play a key role in the tumorigenesis
of a variety of cancers.;
Origin ID : C200854;
concept_is_in_subset
