Preferred Label : Goserelin Acetate Extended-release Microspheres LY01022;
NCIt synonyms : Goserelin Acetate ER Microspheres LY01022; Long-acting Goserelin Microspheres LY01022; Goserelin Acetate Sustained-release Microspheres LY01022; Goserelin Acetate SR Microspheres LY01022;
NCIt definition : A long-acting, extended-release (ER) microsphere formulation of the acetate form of
goserelin, a synthetic decapeptide analog of luteinizing hormone-releasing hormone
(LHRH), with potential antineoplastic activity. Upon administration of goserelin acetate
ER microspheres LY01022, goserelin is released over an extended period of time and
binds to and activates pituitary gonadotropin-releasing hormone (GnRH) receptors.
Prolonged administration of goserelin inhibits the secretion of pituitary gonadotropin,
thereby decreasing levels of testosterone (in males) and estradiol (in females). Administration
of the goserelin ER formulation may result in the regression of sex hormone-sensitive
tumors and a reduction in sex organ size and function. LY01022 prolongs the dosing
cycle to a three-month period, thereby reducing the frequency of injections and potentially
improving compliance.;
Molecule name : LY 01022; LY-01022;
Origin ID : C200827;
concept_is_in_subset
