Preferred Label : Gallium Ga 68 NY104;
NCIt synonyms : Gallium Ga 68 NYM005; 68Ga-NYM005; 68Ga-NY104;
NCIt definition : A radioconjugate composed of NY104, a small molecule carbonic anhydrase IX (CAIX;
carbonic anhydrase 9; CA9; G250)-targeting tracer comprised of an acetazolamide core,
a hydrophilic spacer and the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic
acid (NOTA), labeled with the radionuclide gallium Ga 68, with potential use as a
tracer for CAIX-expressing tumor cells during positron emission tomography (PET).
Upon administration of gallium Ga 68 NY104, the NY104 moiety targets and binds to
CAIX-expressing tumor cells. Upon binding, CAIX-expressing tumor cells can be detected
during PET. CAIX, a member of the carbonic anhydrase family and a tumor-associated
antigen (TAA), is found in a majority of renal cell carcinomas while absent in most
normal tissues.;
NCI Metathesaurus CUI : CL1915105;
Origin ID : C200825;
UMLS CUI : C5856418;
Semantic type(s)
- concept_is_in_subset
