Preferred Label : DPPG2-based Thermosensitive Liposomes Encapsulating Doxorubicin DPPG2-TSL-DOX;
NCIt synonyms : DPPG2-based TSL-encapsulating Doxorubicin DPPG2-TSL-DOX; DPPG2-TSL-DOX;
NCIt definition : A temperature-sensitive liposomal formulation composed of phosphatidylglycerol-based
thermosensitive liposomes (DPPG2-TSL) encapsulating the anthracycline antineoplastic
antibiotic doxorubicin, with potential antineoplastic activity. Upon intravenous administration,
the DPPG2-based thermosensitive liposomes encapsulating doxorubicin DPPG2-TSL-DOX
circulate in the bloodstream, extravasate and are activated locally by applying regional
hyperthermia (RHT), which increases the tumor temperature to between 41.5 and 44 degrees
Celsius using an external heat source. The elevated temperature causes compositional
changes in the liposomes, creating openings that allow for the release of encapsulated
doxorubicin. Doxorubicin intercalates DNA, interferes with the activity of topoisomerase
II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition
and apoptosis. This agent also interacts with cell membrane lipids causing lipid peroxidation.
Compared to non-thermosensitive liposomes, lyso-thermosensitive liposomes deliver
higher concentrations of a cytotoxic agent to a heat-treated tumor site while sparing
normal tissues unexposed to heat treatment.;
Origin ID : C200822;
concept_is_in_subset
