Preferred Label : Copper Cu 64 GRIP B;
NCIt synonyms : 64Cu-labeled GRIP B; 64Cu-GRIP B;
NCIt definition : A radioconjugate composed of granzyme targeting restricted interaction peptide specific
to family member B (GRIP B), a nontoxic antimicrobial peptide (AMP), labeled with
the radioisotope copper Cu 64 linked to a peptide masking domain via a granzyme B
(GZMB) cleavage site, with potential use as a tracer for GZMB activity during positron
emission tomography (PET). Upon administration of copper Cu 64 GRIP B and its cleavage
by GZMB, the radiolabeled AMP is released, adopts its preferred helical conformation,
and binds to nearby phospholipid bilayers such as the plasma membrane of tumor cells.
This allows the detection and visualization of GZMB activity upon PET imaging. GZMB,
a pro-apoptotic serine protease, is released by cytotoxic lymphocytes and plays an
important role in cytotoxicity against virus-infected and tumor cells.;
NCI Metathesaurus CUI : CL1915098;
Origin ID : C200818;
UMLS CUI : C5855614;
Semantic type(s)
- concept_is_in_subset
