Preferred Label : Copper Cu 64 EB-ss-CPT;
NCIt synonyms : 64Cu-EB-ss-CPT; Copper Cu 64-labeled CPT-ss-EB; 64Cu-EB-CPT;
NCIt definition : A radioconjugate composed of the amphiphilic camptothecin (CPT) prodrug EB-ss-CPT,
labeled with the radioisotope copper Cu 64, with potential use as a tracer for tumor
cells during positron emission tomography (PET). EB-ss-CPT is composed of CPT conjugated,
via a redox-responsive disulfide linker, to an albumin-binding Evans blue (EB) derivative.
Upon administration of copper Cu 64 EB-ss-CPT, the EB-ss-CPT moiety binds to endogenous
albumin and the resulting albumin-bound nanocomplex accumulates in tumor cells. This
allows the detection and visualization of tumor cells upon PET imaging.;
NCI Metathesaurus CUI : CL1915081;
Origin ID : C200817;
UMLS CUI : C5856414;
Semantic type(s)
- concept_is_in_subset
