Preferred Label : Carbon C 14 Lerociclib;
NCIt synonyms : 14C-GB491; [14C]GB491; 14C-Lerociclib;
NCIt definition : An orally bioavailable radioconjugate composed of lerociclib, an orally bioavailable
inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), radiolabeled
with the radioisotope carbon C 14, with potential use for evaluating the pharmacokinetic
profile of lerociclib. Upon administration, carbon C 14 lerociclib selectively inhibits
CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early
in the G1 phase, prevents CDK-mediated G1-S phase transition and leads to cell cycle
arrest. This suppresses DNA replication and decreases tumor cell proliferation. Labeling
of lerociclib with the radioactive tracer carbon C 14 allows for the evaluation of
lerociclib's pharmacokinetic profile, including its absorption, distribution, metabolism
and excretion (ADME).;
NCI Metathesaurus CUI : CL1915077;
Origin ID : C200813;
UMLS CUI : C5856413;
Semantic type(s)
- concept_is_in_subset
