Preferred Label : Anti-VISTA Monoclonal Antibody SNS-101;
NCIt synonyms : Conditionally Active VISTA-blocking Antibody SNS-101; VISTA-blocking Monoclonal Antibody SNS-101;
NCIt definition : A conditionally active, pH-sensitive human immunoglobulin (Ig) G1 monoclonal antibody
directed against the negative immune checkpoint regulatory protein V-domain Ig suppressor
of T-cell activation (VISTA; programmed death 1 homolog; PD1H; PD-1H), with potential
negative immune checkpoint regulatory and antineoplastic activities. Upon administration,
anti-VISTA monoclonal antibody SNS-101 selectively targets, binds to and blocks the
VISTA checkpoint within a low, acidic pH tumor microenvironment (TME). This prevents
the interaction of VISTA with its receptor PSGL-1 on T-cells, inhibits VISTA-mediated
signaling, decreases the presence of monocytic myeloid-derived suppressor cells (MDSCs),
increases the presence of natural killer cells (NKs), activates dendritic cells (DCs)
and abrogates VISTA-induced suppression of T-lymphocyte immune responses. This enhances
cytotoxic T-cell infiltration, proliferation, and activation within the TME, increases
cytokine production by T-cells, and inhibits tumor cell growth. VISTA, a negative
checkpoint molecule of immune activation, is highly expressed on myeloid cells, T-cells
and in several tumor types. It plays a key role in the suppression of T-cell function
and tumor immunosuppression.;
Molecule name : SNS 101; SNS-101;
NCI Metathesaurus CUI : CL1915088;
Origin ID : C200808;
UMLS CUI : C5854596;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
