NCIt definition : A bispecific antibody targeting both the tumor-associated antigen (TAA) carcinoembryonic
antigen-related cell adhesion molecule 5 (CEACAM5; CEA) and CD3 antigen found on T-lymphocytes,
with potential immunostimulating and antineoplastic activities. Upon administration,
anti-CEA/anti-CD3 bispecific antibody BA1202 targets and binds to both CEA expressed
on tumor cells and CD3 on cytotoxic T-lymphocytes (CTLs). This activates and redirects
CTLs to CEA-expressing tumor cells, which results in the CTL-mediated cell death of
CEA-expressing tumor cells. CEA is overexpressed by a variety of cancer cell types
and plays a key role in cell migration, cell invasion, and cell adhesion.;
Semantic type(s)