Preferred Label : Anti-CEA/Anti-CD3 Bispecific Antibody BA1202;
NCIt synonyms : CEA x CD3 Bispecific Antibody BA1202; Anti-CD3/Anti-CEA Bispecific Antibody BA1202; Anti-CEACAM5/Anti-CD3 Bispecific Antibody BA1202; Anti-CEA/CD3 Bispecific Antibody BA1202;
NCIt definition : A bispecific antibody targeting both the tumor-associated antigen (TAA) carcinoembryonic
antigen-related cell adhesion molecule 5 (CEACAM5; CEA) and CD3 antigen found on T-lymphocytes,
with potential immunostimulating and antineoplastic activities. Upon administration,
anti-CEA/anti-CD3 bispecific antibody BA1202 targets and binds to both CEA expressed
on tumor cells and CD3 on cytotoxic T-lymphocytes (CTLs). This activates and redirects
CTLs to CEA-expressing tumor cells, which results in the CTL-mediated cell death of
CEA-expressing tumor cells. CEA is overexpressed by a variety of cancer cell types
and plays a key role in cell migration, cell invasion, and cell adhesion.;
Molecule name : BA 1202; BA-1202;
Origin ID : C200797;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
