NCIt definition : An immunoglobulin G1 (IgG1) Fc-silent human monoclonal antibody directed against the
cell surface receptor CD39 (cluster of differentiation 39; ectonucleoside triphosphate
diphosphohydrolase-1; NTPDase1; ENTPD1), with potential immunomodulating and antineoplastic
activities. Upon administration, anti-CD39 monoclonal antibody AB598 specifically
targets and binds to the CD39 antigen, thereby preventing the conversion and degradation
of adenosine triphosphate (ATP) to adenosine monophosphate (AMP). This leads to an
increase in the extracellular levels of immunogenic ATP and a decrease in the levels
of immunosuppressive adenosine within the tumor microenvironment (TME). A high level
of ATP increases pro-inflammatory cytokine levels and promotes both T-cell proliferation
and the stimulation of dendritic and other myeloid-derived cells that are necessary
for innate and adaptive immunity. CD39, a cell surface ectonucleosidase, is upregulated
on tumor cells as an immune evasion strategy; blocking its action may improve anti-tumor
immune responses.;
Semantic type(s)