Preferred Label : Allogeneic EBV-transformed B-lymphoblastoid Cell Line Lysate-pulsed Autologous Dendritic
Cell Vaccine KSD-101;
NCIt synonyms : Allogeneic EBV-transformed BLCL Lysate-pulsed Autologous DC Vaccine KSD-101;
NCIt definition : A cell-based cancer vaccine composed of autologous monocyte-derived dendritic cells
(DCs) pulsed with allogeneic Epstein-Barr virus (EBV)-transformed B-lymphoblastoid
cell line (BLCL) lysate, with potential immunostimulatory and antineoplastic activities.
Upon leukapheresis, DCs are loaded with allogeneic EBV-transformed BLCL lysate. Upon
re-administration of the allogeneic EBV-transformed BLCL lysate-pulsed autologous
DC vaccine KSD-101, the immune system is exposed to EBV-specific antigens, which stimulates
the induction of a specific cytotoxic T-lymphocyte (CTL) response against EBV-positive
tumor cells or EBV-infected cells. This results in cell lysis and inhibition of cancer
cell proliferation. EBV, a ubiquitous human herpes virus, is associated with various
malignancies.;
Molecule name : KSD-101; KSD 101;
NCI Metathesaurus CUI : CL1915072;
Origin ID : C200792;
UMLS CUI : C5854579;
Semantic type(s)
- concept_is_in_subset
