" /> Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes CRG-022 - CISMeF





Preferred Label : Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes CRG-022;

NCIt synonyms : Autologous Anti-CD22-CAR m971-BBz T-cells CRG-022;

NCIt definition : Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of an anti-CD22 single chain variable fragment (scFv) derived from the monoclonal antibody (moAb) 971 (m971), and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD22-CAR m971-BBz lentiviral vector-transduced autologous T-lymphocytes CRG-022 express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing tumor cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells. m971 binds to a membrane proximal epitope on CD22 and has a higher binding affinity compared to other anti-CD22 moAb.;

Molecule name : CRG-022; CRG 022;

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15/05/2024


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