Preferred Label : Anti-CD22-CAR m971-BBz Lentiviral Vector-transduced Autologous T Lymphocytes CRG-022;
Obsolete resource : true;
NCIt synonyms : Autologous Anti-CD22-CAR m971-BBz T-cells CRG-022;
NCIt definition : Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding
a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of an anti-CD22
single chain variable fragment (scFv) derived from the monoclonal antibody (moAb)
971 (m971), and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain
of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic
activities. Upon administration, the anti-CD22-CAR m971-BBz lentiviral vector-transduced
autologous T-lymphocytes CRG-022 express anti-CD22-CAR on their cell surfaces and
bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing tumor
cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein,
is expressed on malignant B-cells. m971 binds to a membrane proximal epitope on CD22
and has a higher binding affinity compared to other anti-CD22 moAb.;
NCIt note : See 'Firicabtagene Autoleucel(C203126)';
Concept status : Retired_Concept;
Molecule name : CRG-022; CRG 022;
NCI Metathesaurus CUI : CL1915414;
Origin ID : C200763;
UMLS CUI : C5854577;
Semantic type(s)
- Cell [UMLS semantic type]
