Preferred Label : Signal Recognition Particle Ribonucleoprotein Complex;
NCIt synonyms : Signal Recognition Particle Complex; SRP Complex; SRP Ribonucleoprotein Complex; Signal Recognition Particle;
NCIt related terms : SRP;
NCIt definition : A ribonucleoprotein complex that targets certain nascent proteins to the endoplasmic
reticulum (ER) during translation. In eukaryotes, the signal recognition particle
complex (SRP) recognizes the N-terminal hydrophobic signal peptide sequence on nascent
peptide chains as they emerge from the ribosome. Next, the SRP slows translation and
docks the complex of the ribosome and nascent peptide with the SRP receptor and translocon
channel that are co-located in the membrane of the ER. Then, the SRP is released and
translation elongation resumes.;
Alternative definition : CDISC: An antigen derived from the ribonucleoprotein complex that targets signal peptide-bearing
proteins to the prokaryotic plasma membrane or the eukaryotic endoplasmic reticulum
membrane for secretion or membrane insertion. It can be considered as an autoantigen
and is commonly associated with the autoimmune disease polymyositis.;
NCIt note : In humans, the signal recognition particle is comprised of 6 proteins (SRP-9, -14,
-19, -54, -68, and -72) and three 7SL RNA components (RN7SL1, RN7SL2 and RN7SL3).; Autoantibodies targeting the signal recognition particle are associated with polymyositis.;
Origin ID : C200610;
concept_is_in_subset
- gene_product_plays_role_in_biological_process
