Preferred Label : Human Factor XIII Concentrate;
NCIt synonyms : Factor XIII Concentrate Human, Plasma Derived; Human FXIII Concentrate; Factor XIII Human; Human Factor XIII; FXIII; Factor XIII Concentrate Human; Fibrinoligase;
NCIt related terms : FACTOR XIII CONCENTRATE (HUMAN);
NCIt definition : A concentrate of coagulation factor XIII (FXIII), a heterotetramer that contains two
enzymatic A-subunits and two non-enzymatic B-subunits, derived from pooled human plasma
from donors, that can be used for prophylactic treatment to prevent bleeding episodes
and to avoid surgical bleeds in patients with congenital FXIII deficiency. Upon intravenous
administration of human FXIII concentrate, FXIII replaces missing endogenous FXIII.
FXIII is activated by thrombin to its activated form FXIIIa, a transglutaminase enzyme
that consists of a dimer of two active A units. FXIIIa promotes crosslinking of fibrin
during coagulation, thereby stabilizing fibrin clots and protecting the fibrin clots
against fibrinolysis, and preventing bleeding. FXIII, also called fibrin stabilizing
factor, is an endogenous plasma glycoprotein.;
UNII : F7R0FBC1XD;
CAS number : 9013-56-3;
Drug name : Corifact;
NCI Metathesaurus CUI : CL1915296;
Codes from synonyms : 210;
Origin ID : C200601;
UMLS CUI : C2979805;
Semantic type(s)
- concept_is_in_subset
