Preferred Label : B7H3/CD3-targeting T-cell Engaging Molecule TAK-280;
NCIt synonyms : Conditionally Active T-cell Engager TAK-280; COBRA Protein TAK-280; B7H3/CD3-engaging Conditionally Active Bispecific Antibody TAK-280; B7H3 x CD3 T-BsAb TAK-280; B7H3 x CD3 Conditional Bispecific Redirected Activation Protein TAK-280;
NCIt definition : A T-cell engaging bispecific antibody and Conditional Bispecific Redirected Activation
(COBRA) protein targeting both the tumor-associated antigen (TAA) and immunoregulatory
protein B7-homologue 3 (B7-H3, CD276) and the T-cell surface antigen CD3, with potential
immunostimulating and antineoplastic activities. Upon intravenous administration,
B7H3/CD3-targeting T-cell engaging molecule TAK-280 is cleaved by proteases in the
tumor microenvironment (TME). Upon cleavage, TAK-280 is activated and binds to both
CD3 on cytotoxic T-lymphocytes (CTLs) and B7H3 on B7H3-expressing tumor cells. This
activates and redirects CTLs to B7H3-expressing tumor cells, leading to a CTL-mediated
killing of B7H3-expressing tumor cells. B7-H3, a type I transmembrane protein and
a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain
tumor cell types and on various immune cells. It is a negative regulator of T-cell
activation and its overexpression plays a key role in tumor cell invasion and metastasis.;
Molecule name : MVC 280; MVC-280; TAK-280; TAK 280;
Origin ID : C200591;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
