Preferred Label : Mirivadelgat;
NCIt synonyms : Aldehyde Dehydrogenase 2 Activator FP-045; ALDH2 Activator FP-045;
NCIt definition : An orally bioavailable selective activator of the mitochondrial isoform of aldehyde
dehydrogenase (ALDH2), with potential protective activity. Upon oral administration,
mirivadelgat increases ALDH2 activity. This increases the metabolism of toxic reactive
aldehydes and lowers the level of the toxic aldehydes. This may protect cells from
the toxic aldehydes and prevent mitochondria diseases and disorders. ALDH2, a mitochondrial
regulator of toxic aldehyde metabolism, plays an important role in the metabolism
of toxic aldehydes. Toxic aldehydes are produced by oxidative stress.;
UNII : 22TB7Q431D;
CAS number : 1804941-96-5;
Molecule name : FP 045; FP-045;
NCI Metathesaurus CUI : CL1915292;
Origin ID : C200589;
UMLS CUI : C5854572;
Semantic type(s)
- concept_is_in_subset
- has_target
