Preferred Label : Anti-GARP Monoclonal Antibody JYB1907;
NCIt synonyms : Anti-glycoprotein A Repetitions Predominant Monoclonal Antibody JYB1907;
NCIt definition : A humanized monoclonal antibody directed against the transforming growth factor beta
(TGFbeta) activator glycoprotein A repetitions predominant (GARP; leucine-rich repeat-containing
protein 32; LRRC32), with potential immunomodulating and antineoplastic activities.
Upon administration, anti-GARP monoclonal antibody JYB1907 selectively targets and
binds to GARP. This specifically blocks the GARP-mediated release of the cytokine
transforming growth factor-beta 1 (TGF-b1), thereby relieving the immunosuppression
caused by TGF-b1 and reversing the immunosuppressive nature in the tumor microenvironment
(TME). This improves anti-tumor immune responses GARP, a transmembrane protein highly
expressed on activated, immunosuppressive regulatory T-cells (Tregs) in the TME, is
essential for the expression of TGF-b1 on the cell surface of activated Tregs; it
plays an important role in regulation of the immune cell function and the immunosuppressive
nature of Tregs. TGF-b1 stimulates stromal cell proliferation, neovascularization,
cancer cell metastasis, and inhibits immune cell infiltration.;
Molecule name : JYB 1907; JYB-1907;
NCI Metathesaurus CUI : CL1907547;
Origin ID : C200547;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
