Preferred Label : Anti-B7H7 Monoclonal Antibody HBM1020;
NCIt synonyms : Anti- Monoclonal Antibody HBM1020;
NCIt definition : A recombinant human monoclonal antibody directed against HERV-H LTR-associating protein
2 (HHLA2; B7 homolog 7; B7H7), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon administration, anti-B7H7 monoclonal antibody HBM1020 binds to B7H7
and blocks the interaction between B7H7 and its receptors. This abrogates the B7H7-mediated
inhibition of T-cell and nature killer (NK) cell activation, which may lead to enhanced
cytotoxic T-lymphocyte (CTL)-mediated immune response and NK cell cytotoxicity against
cancer cells. B7H7, a member of the B7 family of immune modulators, is upregulated
in a variety of tumor cell types and a negative regulator of T-cell and NK cell activation.;
Molecule name : HBM 1020; HBM-1020;
NCI Metathesaurus CUI : CL1907535;
Origin ID : C200543;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
