Anti-B7H7 Monoclonal Antibody HBM1020

Preferred Label : Anti-B7H7 Monoclonal Antibody HBM1020;

NCIt synonyms : Anti- Monoclonal Antibody HBM1020;

NCIt definition : A recombinant human monoclonal antibody directed against HERV-H LTR-associating protein 2 (HHLA2; B7 homolog 7; B7H7), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-B7H7 monoclonal antibody HBM1020 binds to B7H7 and blocks the interaction between B7H7 and its receptors. This abrogates the B7H7-mediated inhibition of T-cell and nature killer (NK) cell activation, which may lead to enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response and NK cell cytotoxicity against cancer cells. B7H7, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and a negative regulator of T-cell and NK cell activation.;

Molecule name : HBM 1020; HBM-1020;

NCI Metathesaurus CUI : CL1907535;

Details

Origin ID

C200543;

UMLS CUI

C5854552;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- HERV-H LTR-Associating Protein 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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