NCIt definition : The investigation of the collective impact of variations across a genome on drug responses.;
Alternative definition : NCI-GLOSS: The study of how a person's genes affect the way he or she responds to
drugs. Pharmacogenomics is being used to learn ahead of time what the best drug or
the best dose of a drug will be for a person.; CDISC-GLOSS: Science that examines inherited variations in genes that dictate drug
response and explores the ways such variations can be used to predict whether a person
will respond favorably, adversely, or not at all to an investigational product.; CDISC: The study of inherited variations in genes that determine and can be used to
predict how an individual will respond to a drug or treatment.;
NCIt note : The term is applicable to activities such as drug discovery, drug development, and
clinical practice. Drug response includes drug disposition (pharmacokinetics, PK)
and drug effect (pharmacodynamics, PD). The term drug should be considered synonymous
with investigational (medicinal) product, medicinal product and pharmaceutical (including
vaccines and other biological products).The definition of does not include other disciplines
such as proteomics and metabonomics.;