Preferred Label : TCR-engineered T-cells HRYZ-T101;
NCIt synonyms : TCR-T Cells HRYZ-T101;
NCIt definition : A preparation of genetically engineered T-lymphocytes expressing a T-cell receptor
(TCR) targeting a specific tumor-associated antigen (TAA) of the human papillomavirus
(HPV) type 18 (HPV-18), with potential antineoplastic activity. Upon administration,
HPV-18 expressing TCR T-cells target and bind to tumor cells expressing the HPV-18
TAA leading to selective cytotoxicity in HPV-18 TAA-expressing tumor cells. HPV18
TAAs are overexpressed in a variety of tumor cell types.;
Molecule name : HRYZ T101; HRYZ-T101;
NCI Metathesaurus CUI : CL1907469;
Origin ID : C200468;
concept_is_in_subset
