Preferred Label : Gallium Ga 68/Copper Cu 64-labeled FAPI-XT117;
NCIt synonyms : 68Ga/64Cu-FAPI-XT117;
NCIt definition : A radioconjugate composed of FAPI-XT117, a fibroblast activation protein inhibitor
(FAPi), labeled with the radionuclides gallium Ga 68 and copper Cu 64, with potential
use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron
emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga
68/copper Cu 64-labeled FAPI-XT117, the FAPI-XT117 moiety targets and binds to FAP-expressing
CAFs. Upon binding, FAP-expressing cells can be detected during PET/CT imaging. FAP,
a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME).;
NCI Metathesaurus CUI : CL1907463;
Origin ID : C200463;
UMLS CUI : C5856253;
Semantic type(s)
- concept_is_in_subset
