Preferred Label : EGFR Mutant-selective Inhibitor YK-029A;
NCIt synonyms : EGFR TKI Inhibitor YK-029A; Mutant-selective EGFR Inhibitor YK-029A; EGFR Inhibitor YK-029A;
NCIt definition : An orally bioavailable, mutant-selective, third-generation epidermal growth factor
receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration,
EGFR mutant-selective inhibitor YK-029A targets, binds to and inhibits the activity
of EGFR with exon 20 insertion (Ex20ins) activating mutations, the gatekeeper mutation
T790M and some other rare mutations, thereby preventing EGFR-mediated signaling. This
may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells.
EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role
in tumor cell proliferation and tumor vascularization.;
Molecule name : YK-029A; YK 029A;
NCI Metathesaurus CUI : CL1907464;
Origin ID : C200462;
concept_is_in_subset
- has_target
