Preferred Label : Pruvonertinib;
NCIt synonyms : EGFR TKI YK-029A; Mutant-selective EGFR Inhibitor YK-029A; EGFR Inhibitor YK-029A; EGFR Mutant-selective Inhibitor YK-029A;
NCIt definition : An orally bioavailable, mutant-selective, third-generation epidermal growth factor
receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration,
pruvonertinib targets, binds to and inhibits the activity of EGFR with exon 20 insertion
(Ex20ins) activating mutations, the gatekeeper mutation T790M and some other rare
mutations, thereby preventing EGFR-mediated signaling. This may both induce cell death
and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine
kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation
and tumor vascularization.;
UNII : HXJ9459HFK;
CAS number : 2064269-82-3;
Molecule name : YK-029A; YK 029A;
NCI Metathesaurus CUI : CL1907464;
Origin ID : C200462;
UMLS CUI : C5854542;
Semantic type(s)
- concept_is_in_subset
- has_target
