Preferred Label : Anti-IGFBP2 Plasmid DNA Vaccine AST-201;
NCIt synonyms : pUMVC3-hIGFBP-2 Multi-epitope Plasmid DNA Vaccine AST201; Therapeutic Cancer Vaccine AST-201; pUMVC3-hIGFBP-2-based Vaccine AST201; IGFBP2 Vaccine AST201;
NCIt definition : A polyepitope plasmid DNA therapeutic cancer vaccine containing the mammalian expression
vector pUMVC3 encoding multiple epitopes derived from tumor-associated antigens (TAAs):
human insulin-like growth factor-binding protein 2 (IGFBP2), with potential immunostimulating
and antineoplastic activities. Upon intradermal vaccination, anti-IGFBP2 plasmid DNA
vaccine AST-201 enters cells which process the plasmid, and express the epitopes and
present them to antigen-presenting cells (APCs). This activates the immune system
to mount a combined response from specific T-helper type 1 (Th1) cells, memory T-cells
and cytotoxic T-lymphocytes (CTL) against IGFBP2-expressing tumor cells. IGFBP2, overexpressed
in certain tumor cell types, plays a key role in cellular proliferation and survival.;
Molecule name : AST 201; AST-201;
NCI Metathesaurus CUI : CL1907465;
Origin ID : C200457;
UMLS CUI : C5854537;
Semantic type(s)
- concept_is_in_subset
- has_target
