Preferred Label : Sodium Pentaborate Pentahydrate;
NCIt synonyms : Sodium Pentaborate; SPP;
NCIt definition : The pentahydrate sodium salt form of the naturally occurring mineral and element boron,
with potential radioprotective, cryoprotective, antioxidant, apoptotic, wound healing,
anti-inflammatory and antineoplastic activities. Upon administration, sodium pentaborate
appears to exert various anticancer and protective activities via multiple mechanisms
of actions (MoAs) even though the exact MoAs have yet to be fully elucidated. Sodium
pentaborate causes gene expression alterations of multiple essential genes, affecting
both upregulations and downregulations. Many of the dysregulated genes serve key roles
in various biological processes, including the inflammation response, stress response,
cellular growth, proliferation, apoptosis and tumorigenesis/oncolysis. Specifically,
the upregulation of proapoptotic genes may induce cell cycle arrest at different phases
and may decrease tumor cell proliferation in susceptible tumor cells. Sodium pentaborate
may also induce oxidative stress which results in the production of reactive oxygen
species (ROS) and in enhanced apoptosis, thereby further inducing tumor cell apoptosis.;
NCI Metathesaurus CUI : CL1907453;
Origin ID : C200453;
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