Preferred Label : CD80-Fc Fusion Protein KM602;
NCIt definition : A recombinant fusion protein composed of the extracellular domain (ECD) of human CD80
(B7.1) fused to a human immunoglobulin G1 (IgG1) Fc fragment, with potential immunostimulatory,
immune checkpoint inhibitory and antineoplastic activities. Upon administration of
CD80-Fc fusion protein KM602, the CD80 moiety targets and binds to CD28, which in
the presence of antigenic T-cell receptor (TCR) signaling, leads to the co-stimulation
of T-cell responses including the activation of naive and memory T-cells. This leads
to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby
killing cancer cells. KM602 also targets and binds to CTL-associated antigen 4 (CTLA4;
CTLA-4), which prevents the binding of CTLA-4 to endogenous CD80 and enables CD80-CD28
engagement, CD28 signaling, and T-cell activation in the tumor microenvironment (TME).
In addition, KM602 binds to the immunosuppressive ligand human programmed cell death-1
ligand 1 (PD-L1; cluster of differentiation 274; CD274), which prevents the binding
of PD-L1 to CD80 and enables CD80-CD28 engagement, CD28 signaling, and T-cell activation
in the TME as well as abrogating the binding of PD-L1 to its receptor programmed cell
death 1 (PD-1; cluster of differentiation 279; CD279) and preventing PD-L1/PD-1-mediated
signaling, which further enhances an anti-tumor immune response. CD80 is a co-stimulatory
molecule expressed on activated antigen presenting cells (APCs) that plays a key role
in T-cell activation upon binding to CD28 on T-cells. On the other hand, binding of
CD80 to CTLA-4 prevents CD80-CD28 engagement, thereby inhibiting T-cell activity and
immune activation, and T-cell exhaustion. CTLA-4, a member of the immunoglobulin superfamily
(IgSF) and an inhibitory molecule, is upregulated by T-cells following T-cell activation
and plays a key role in the downregulation of the immune system. PD-1, found on activated
T-cells, negatively regulates T-cell activity; it plays a key role in immune evasion
and prevents tumor cell lysis. PD-L1 is often overexpressed on tumor cell types and
plays a key role in immune evasion.;
Molecule name : KM 602; KM-602; XZP-KM602;
NCI Metathesaurus CUI : CL1907458;
Origin ID : C200448;
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