Preferred Label : Heat Shock Factor 1 Pathway Inhibitor NXP800;
NCIt synonyms : HSF1 Pathway Inhibitor NXP800;
NCIt definition : An orally bioavailable fluorobisamide and heat shock factor 1 (HSF1) pathway inhibitor,
with potential antineoplastic activity. Upon oral administration, HSF1 pathway inhibitor
NXP800 targets and inhibits the activity of the HSF1-regulated pathway, thereby preventing
HSF1-mediated transcription. This inhibits proliferation, migration, survival, and
metastasis in susceptible tumor cells, especially in AT-rich interaction domain 1A
(ARID1A)-mutated cancer cells. HSF1, a stress-inducible transcription factor that
plays a key role in the transcriptional activation of the eukaryotic heat shock response;
its activation leads to expression of many heat shock proteins (HSPs). Overexpressed,
amplified and/or overactivated in many cancer cells, HSF1 activates a set of genes
that play a key role in tumor initiation, progression and metastasis.;
Molecule name : CCT 361814; CCT-361814; VK2019; NXP-800;
NCI Metathesaurus CUI : CL1907445;
Origin ID : C200434;
concept_is_in_subset
