Preferred Label : Oncolytic Adenovirus ICVB-1042;
NCIt definition : A genetically-engineered, replication competent, optimized E2 transcription factor
(E2F)-dependent oncolytic adenovirus (Ad) composed of an Ad serotype 5 (Ad5) backbone
that contains genomic modifications to include an Ad5/Ad34 chimeric fiber and dual
modifications in E1A and E4orf6/7, and a modified capsid hexon protein, with potential
antineoplastic activity. Upon administration, the oncolytic adenovirus ICVB-1042 selectively
targets and binds to CD46 that is overexpressed on many cancer cells. Upon viral entry,
ICVB-1042 infects and specifically replicates in tumor cells, which may result in
tumor cell lysis. ICVB-1042 replicates only in cells with defects in the p16/Rb/E2F
pathway, attributed to a mutation common in many solid tumors, and protects normal,
non-proliferative cells from viral-mediated toxicity. The Ad5/Ad34 mutation improves
viral entry into target tumor cells, enhancing tropism by enabling and increasing
viral entry via CD46. The modifications in E1A and E4orf6/7 increases tumor selectivity.
The modified capsid hexon protein allows for IV delivery and mediates cell interaction
with CD46. ICVB-1042 includes expression of a fluorescent reporter protein (YPet)
to aid in tracking viral replication.;
Molecule name : ICVB-1042; ICVB 042; ICVB 1042;
NCI Metathesaurus CUI : CL1907418;
Origin ID : C200413;
concept_is_in_subset
